Welcome to K.R. Prasad's Home Page

Associate Professor

Department of Organic Chemistry

Tel: 080-2293-2524

Fax: 080-2360-0529

E-mail: prasad@orgchem.iisc.ernet.in


Education: (CV here); One-page summary

Ph. D. National Chemical Laboratory, Pune (with Dr.N. N. Joshi)

Post-doc (1)Alexander von Humboldt Foundation fellow, Universität Münster (with Prof. Dieter Hoppe), (2) Temple University, Philadelphia, (with Prof. Franklin A. Davis)


Research Interests

Summary

In our research group we focus on all aspects of asymmetric synthesis. Our research program is primarily directed in the design and development of asymmetric methodologies that can execute transformations with complete diastero and enantioselection. This perfect stereocontrolled synthesis by asymmetric catalysis using either organometallic reagents or with the aid of small organic molecules as catalysts will be explored. These catalysts will be developed from abundantly available resources, which are cheap, reusable, non-toxic and easily modifiable. Ultimately, we combine the versatility of the asymmetric methodologies in the synthesis of biologically active molecules and their analogues. This will provide a basis to study the structure-activity relationships of bio-active molecules and their use as potential therapeutics.


Representative Publications

  1. Enantiodivergent synthesis of both antipodes of gypsy moth pheromone disparlure. Prasad, K.R.; Anbarasan, P. J. Org. Chem. 2007 (in press).
  2. Stereoselective total synthesis of ( )-9-deoxy-goniopypyrone. Prasad, K.R.; Dhaware, M. G. Synlett, 2007 (in press).
  3. Stereoselective synthesis of -alkyl(aryl)- , -dihydroxy- -butyrolactones and naturally occurring lipid guggultetrol. Prasad, K.R.; Chandrakumar, A. Tetrahedron 2007, 63, 1798.
  4. Stereoselective synthesis of ( )-centrolobine. Prasad, K.R.; Anbarasan, P. Tetrahedron, 2007, 63, 1089.
  5. Stereoselective synthesis of ( )-microcarapalide. Prasad, K.R.; Penchalaiah, K.; Choudhary, A.; Anbarasan, P. Tetrahedron Lett., 2007, 48, 309.
  6. Stereoselective synthesis of ( )-muricatacin from l-(+)-tartaric acid. Prasad, K. R.; Anbarasan, P. Tetrahedron: Asymmetry, 2006, 17, 2765.
  7. Nucleophilic addition reactions of 1,4-diketones derived from tartaric acid: Synthesis of TADDOL analogues. Prasad, K.R.; Chandrakumar, A. Synthesis, 2006, 2159.
  8. Stereoselective synthesis of (+)-goniothalesdiol. Prasad, K.R.; Gholap, S. L. J. Org. Chem. 2006, 71, 3643.
  9. Stereoselective synthesis of (+)-boronolide and (-)-5-epi-boronolide. Prasad, K.R.; Anbarasan, P. Tetrahedron: Asymmetry, 2006, 17, 1146.
  10. Enantiodivergent synthesis of both antipodes of hydroxy-exo-brevicomin from L-(+)-tartaric acid. Prasad, K.R.; Anbarasan, P. Tetrahedron, 2006, 62, 8303.
  11. Asymmetric synthesis of -methoxyarylacetic acid derivatives. Prasad, K.R.; Chandrakumar, A. Tetrahedron: Asymmetry 2005, 16, 1897.
  12. Asymmetric synthesis of unsaturated -benzyloxyaldehydes: An enantioselective synthesis of (+)-exo-brevicomin. Prasad, K.R.; Anbarasan, P. Tetrahedron: Asymmetry 2005, 16, 3951.
  13. An expeditious enantiospecific total synthesis of (+)-7-epi-goniofufurone. Prasad, K.R.; Gholap, S. L. Synlett, 2005, 2260.

This page is under construction


Back to Organic Chemistry Home Page